Denali Therapeutics (NASDAQ:DNLI) and Its Peers Critical Comparison

Denali Therapeutics (NASDAQ: DNLI) is one of 289 public companies in the “Bio Therapeutic Drugs” industry, but how does it contrast to its competitors? We will compare Denali Therapeutics to related businesses based on the strength of its earnings, dividends, institutional ownership, profitability, risk, valuation and analyst recommendations.

Analyst Recommendations

This is a summary of recent recommendations and price targets for Denali Therapeutics and its competitors, as provided by MarketBeat.

Sell Ratings Hold Ratings Buy Ratings Strong Buy Ratings Rating Score
Denali Therapeutics 0 1 3 0 2.75
Denali Therapeutics Competitors 954 3405 11909 239 2.69

Denali Therapeutics presently has a consensus target price of $24.00, indicating a potential upside of 56.25%. As a group, “Bio Therapeutic Drugs” companies have a potential upside of 40.62%. Given Denali Therapeutics’ stronger consensus rating and higher probable upside, analysts clearly believe Denali Therapeutics is more favorable than its competitors.

Valuation and Earnings

This table compares Denali Therapeutics and its competitors gross revenue, earnings per share (EPS) and valuation.

Gross Revenue Net Income Price/Earnings Ratio
Denali Therapeutics N/A N/A -14.91
Denali Therapeutics Competitors $290.27 million $35.99 million 54.38

Denali Therapeutics’ competitors have higher revenue and earnings than Denali Therapeutics. Denali Therapeutics is trading at a lower price-to-earnings ratio than its competitors, indicating that it is currently more affordable than other companies in its industry.

Institutional & Insider Ownership

49.8% of shares of all “Bio Therapeutic Drugs” companies are held by institutional investors. 16.8% of shares of all “Bio Therapeutic Drugs” companies are held by insiders. Strong institutional ownership is an indication that endowments, hedge funds and large money managers believe a stock is poised for long-term growth.


This table compares Denali Therapeutics and its competitors’ net margins, return on equity and return on assets.

Net Margins Return on Equity Return on Assets
Denali Therapeutics N/A N/A N/A
Denali Therapeutics Competitors -5,322.24% -84.37% -35.66%


Denali Therapeutics beats its competitors on 6 of the 11 factors compared.

Denali Therapeutics Company Profile

Denali Therapeutics Inc. is a biotechnology company. The Company is focused on the discovery and development of therapies for patients with neurodegenerative disease, including Alzheimer’s disease, Parkinson’s disease, amyotrophic lateral sclerosis (ALS) and others. The Company is developing a diversified portfolio of therapeutics, based on scientific insights into the genetic causes and biological processes underlying neurodegenerative disease. The Company has selected approximately four specific pathways that are implicated as triggers or effectors of neurodegeneration, including degenogenes (genes that cause neurodegenerative disease when mutated), defective intracellular trafficking, glial dysfunction and axon degeneration. The Company’s development programs include Lysosomal Function Pathway, Glial Biology Pathway, and Cellular Homeostasis Pathway. Its product pipeline includes drug candidates such as DNL201, DNL 151, ATV:aSyn, ETV:IDS, DNL747, and ATV:TREM2.

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